There have been some issues with mod_rewrite, WordPress and the permalink functionality. In some cases, when having mod_rewrite enabled, WordPress fails to load the Settings > Permalink page. Some people experience a blank screen, while others experience a 404 Page Not Found error.
If there are no issues in your .htaccess, and you have exhausted all other options, you may need to modify the WordPress core:
/wp-admin/includes/misc.php
~Line 16, change function got_mod_rewrite() {
to function got_mod_rewrite() {return true;
~Line 42, change function got_url_rewrite() {
to function got_url_rewrite() {return true;
If anyone has any other suggestions, please let us know!